2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2417):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-178629
    DMTr-2'-O-propyl-rA(Bz)-3'-CE-phosphoramidite
    DMTr-2'-O-propyl-rA(Bz)-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-propyl-rA(Bz)-3'-CE-phosphoramidite
  • HY-177775
    pro-N6pA
    pro-N6pA is a cell-permeable pronucleotide probe. Pro-N6pA can be used to track AMPylated proteins. Pro-N6pA can also be used in bacterial infection research.
    pro-N6pA
  • HY-178687
    N2-Isobutyryl-2'-O,4'-C-methyleneguanosine
    N2-Isobutyryl-2'-O,4'-C-methyleneguanosine (2'-O-4'-C-Locked-rG(iBu)) is a monomeric raw material that can be used for nucleic acid synthesis.
    N2-Isobutyryl-2'-O,4'-C-methyleneguanosine
  • HY-178542
    DMTr-2'-F-dG(iBu)-3'-(L)-DPSE-phosphoramidite
    DMTr-2'-F-dG(iBu)-3'-(L)-DPSE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-F-dG(iBu)-3'-(L)-DPSE-phosphoramidite
  • HY-W754015
    5'-O-DMTr-2'-O-Me-rA
    		99.88%
    5'-O-DMTr-2'-O-Me-rA is a monomeric raw material that can be used for nucleic acid synthesis.
    5'-O-DMTr-2'-O-Me-rA
  • HY-178670
    N-Butyl molnupiravir
    N-Butyl molnupiravir is a monomeric raw material that can be used for nucleic acid synthesis.
    N-Butyl molnupiravir
  • HY-178579
    SPS ATP
    SPS ATP is a monomeric raw material that can be used for nucleic acid synthesis.
    SPS ATP
  • HY-145340
    2'-O-Propargyl A(Bz)-3'-phosphoramidite
    2'-O-Propargyl A(Bz)-3'-phosphoramidite is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277). 2'-O-Propargyl A(Bz)-3'-phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    2'-O-Propargyl A(Bz)-3'-phosphoramidite
  • HY-W1008628
    5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu)
    5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) is a monomeric raw material that can be used for nucleic acid synthesis.
    5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu)
  • HY-131759A
    2'-Amino-2'deoxyadenosine-5'-O-diphosphate sodium
    2'-Amino-2'deoxyadenosine-5'-O-diphosphate (2'-NH2-ADP) sodium is an amine-modified nucleotide and a structural analog of the purine nucleotide ADP.
    2'-Amino-2'deoxyadenosine-5'-O-diphosphate sodium
  • HY-171530
    2'-O-MOE-GTP
    2'-O-MOE-GTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-O-MOE-GTP
  • HY-180473
    6-Thio-cGMP
    6-Thio-cGMP is an analog of cyclic guanosine monophosphate (cGMP).
    6-Thio-cGMP
  • HY-W784609
    Spacer C12 phosphoramidite
    Spacer C12 phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    Spacer C12 phosphoramidite
  • HY-134076
    2',3'-Di-O-Methyladenosine
    2',3'-Di-O-Methyladenosine (2',3'-O-Me-rA) is a monomeric raw material that can be used for nucleic acid synthesis.
    2',3'-Di-O-Methyladenosine
  • HY-180680
    2-Methoxyestrone 3-glucuronide
    2-Methoxyestrone 3-glucuronide is a nucleoside metabolite.
    2-Methoxyestrone 3-glucuronide
  • HY-178578
    Cy3-CTP
    Cy3-CTP is a monomeric raw material that can be used for nucleic acid synthesis.
    Cy3-CTP
  • HY-178667
    2'-O-Propargyl-rC(Bz)
    2'-O-Propargyl-rC(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-O-Propargyl-rC(Bz)
  • HY-125650A
    Pseudouridimycin TFA
    Pseudouridimycin (PUM) TFA is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin TFA is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin TFA inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis.
    Pseudouridimycin TFA
  • HY-W393228
    Pseudouridine 5'-phosphate
    Pseudouridine 5'-phosphate is a monomeric raw material that can be used for nucleic acid synthesis.
    Pseudouridine 5'-phosphate
  • HY-178674
    Im-m7GDP
    Im-m7GDP is the cap reagent that can be used for nucleic acid synthesis.
    Im-m7GDP